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Validity of the child health questionnaire for use in children with sickle cell disease. J Pediatr Hematol Oncol 2004 Sep;26(9):574-8 PMID: 15342984

Pubmed ID



OBJECTIVE: To provide accurate data on health-related quality of life (HRQL), there must be a valid tool to measure this outcome. The objective of this study was to determine the validity of the Child Health Questionnaire (CHQ) as a measure of HRQL in sickle cell disease (SCD) by examining the relationship between HRQL and disease severity.

METHODS: This was a cross-sectional study of children conducted at two urban, hospital-based clinics. The study participants were children with SCD ages 5 to 18 years who presented for a routine visit to the comprehensive SCD clinic. The main outcome was HRQL, as measured by the CHQ-Parent Form 28 (PF28). A t test was used to compare HRQL between those with mild and severe disease.

RESULTS: Parents/caretakers of 95 children completed the CHQ-PF28. Children with mild SCD had a significantly better HRQL, as evidenced by a higher mean physical summary score (39.1), than those with severe disease (28.0) (difference=11.1, 95% confidence interval 5.03-18.11). There was no significant difference in psychosocial summary scores between groups.

CONCLUSIONS: The CHQ is a valid tool to assess HRQL in children with SCD and could serve as an important adjunct to determine the effect of SCD on the lives of children.

Author List

Panepinto JA, O'Mahar KM, DeBaun MR, Rennie KM, Scott JP


Julie A. Panepinto MD, MSPH Professor in the Pediatrics department at Medical College of Wisconsin
John Paul Scott MD Professor in the Pediatrics department at Medical College of Wisconsin


2-s2.0-4544300142   39 Citations

MESH terms used to index this publication - Major topics in bold

Anemia, Sickle Cell
Child Welfare
Child, Preschool
Cross-Sectional Studies
Health Status
Health Status Indicators
Outcome Assessment (Health Care)
Quality of Life
Surveys and Questionnaires
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e