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Divalproex sodium extended-release for the prophylaxis of migraine headache. Expert Opin Pharmacother 2003 Sep;4(9):1573-8 PMID: 12943487

Pubmed ID



The Diamond Headache Clinic first began using valproic acid in 1984. Subsequently, a variety of open-label and then placebo-controlled trials were carried out with valproic acid, followed by an enteric-coated formulation known as divalproex sodium delayed-release. These trials demonstrated a consistent pattern of efficacy and the delayed-release form improved tolerability while offering a twice-daily dosing schedule. This led to the development of an extended-release formulation. This formulation further improved tolerability and led to a once-daily dosing. The pivotal trial conducted in patients with migraine with the extended-release formulation demonstrated efficacy similar to that seen with the delayed-release form.

Author List

Freitag FG


Frederick G. Freitag DO Associate Professor in the Neurology department at Medical College of Wisconsin


2-s2.0-0141740241   6 Citations

MESH terms used to index this publication - Major topics in bold

Clinical Trials as Topic
Delayed-Action Preparations
Drug Administration Schedule
GABA Agents
Migraine Disorders
Randomized Controlled Trials as Topic
Valproic Acid
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70