Exploiting pluripotent stem cell technology for drug discovery, screening, safety, and toxicology assessments. Adv Drug Deliv Rev 2014 Apr;69-70:170-8
Date
12/07/2013Pubmed ID
24309014DOI
10.1016/j.addr.2013.11.012Scopus ID
2-s2.0-84899971912 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
In order for the pharmaceutical industry to maintain a constant flow of novel drugs and therapeutics into the clinic, compounds must be thoroughly validated for safety and efficacy in multiple biological and biochemical systems. Pluripotent stem cells, because of their ability to develop into any cell type in the body and recapitulate human disease, may be an important cellular system to add to the drug development repertoire. This review will discuss some of the benefits of using pluripotent stem cells for drug discovery and safety studies as well as some of the recent applications of stem cells in drug screening studies. We will also address some of the hurdles that need to be overcome in order to make stem cell-based approaches an efficient and effective tool in the quest to produce clinically successful drug compounds.
Author List
McGivern JV, Ebert ADAuthor
Allison D. Ebert PhD Associate Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsClinical Trials as Topic
Drug Discovery
Drug Evaluation, Preclinical
Drug-Related Side Effects and Adverse Reactions
High-Throughput Screening Assays
Humans
Pluripotent Stem Cells
