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Diffusion tensor imaging reveals acute subcortical changes after mild blast-induced traumatic brain injury. Sci Rep 2014 May 02;4:4809 PMID: 24786839 PMCID: PMC4019232

Pubmed ID

24786839

DOI

10.1038/srep04809

Abstract

Mild blast-induced traumatic brain injury (mbTBI) poses special diagnostic challenges due to its overlapping symptomatology with other neuropsychiatric conditions and the lack of objective outcome measures. Diffusion tensor imaging (DTI) can potentially provide clinically relevant information toward a differential diagnosis. In this study, we aimed to determine if single and repeated (5 total; administered on consecutive days) mild blast overpressure exposure results in detectable structural changes in the brain, especially in the hippocampus. Fixed rat brains were analyzed by ex vivo DTI at 2 h and 42 days after blast (or sham) exposure(s). An anatomy-based region of interest analysis revealed significant interactions in axial and radial diffusivity in a number of subcortical structures at 2 h only. Differences between single- and multiple-injured rats were largely in the thalamus but not the hippocampus. Our findings demonstrate the value and the limitations of DTI in providing a better understanding of mbTBI pathobiology.

Author List

Kamnaksh A, Budde MD, Kovesdi E, Long JB, Frank JA, Agoston DV

Author

Matthew Budde PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin




Scopus

2-s2.0-84899864979   21 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Brain
Brain Injuries
Diffusion Tensor Imaging
Hippocampus
Male
Organ Size
Rats
Time Factors
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5