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Enhanced survival from radiation pneumonitis by combined irradiation to the skin. Int J Radiat Biol 2014 Sep;90(9):753-61 PMID: 24827855 PMCID: PMC4380176

Pubmed ID

24827855

Abstract

PURPOSE: To develop mitigators for combined irradiation to the lung and skin.

METHODS: Rats were treated with X-rays as follows: (1) 12.5 or 13 Gy whole thorax irradiation (WTI); (2) 30 Gy soft X-rays to 10% area of the skin only; (3) 12.5 or 13 Gy WTI + 30 Gy skin irradiation after 3 hours; (4) 12.5 Gy WTI + skin irradiation and treated with captopril (160 mg/m(2)/day) started after 7 days. Our end points were survival (primary) based on IACUC euthanization criteria and secondary measurements of breathing intervals and skin injury. Lung collagen at 210 days was measured in rats surviving 13 Gy WTI.

RESULTS: After 12.5 Gy WTI with or without skin irradiation, one rat (12.5 Gy WTI) was euthanized. Survival was less than 10% in rats receiving 13 Gy WTI, but was enhanced when combined with skin irradiation (p < 0.0001). Collagen content was increased at 210 days after 13 Gy WTI vs. 13 Gy WTI + 30 Gy skin irradiation (p < 0.05). Captopril improved radiation-dermatitis after 12.5 Gy WTI + 30 Gy skin irradiation (p = 0.008).

CONCLUSIONS: Radiation to the skin given 3 h after WTI mitigated morbidity during pneumonitis in rats. Captopril enhanced the rate of healing of radiation-dermatitis after combined irradiations to the thorax and skin.

Author List

Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M

Authors

Elizabeth R. Jacobs MD Associate Dean, Professor in the Medicine department at Medical College of Wisconsin
Meetha M. Medhora PhD Professor in the Radiation Oncology department at Medical College of Wisconsin
Aniko Szabo PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin




Scopus

2-s2.0-84907045554   4 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Captopril
Collagen
Female
Fibrosis
Lung
Radiation Injuries
Radiation Injuries, Experimental
Radiation Pneumonitis
Rats
Skin
Thorax
Time Factors
Treatment Outcome
Wound Healing
X-Rays
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6