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Determinants of pressure drift in Manoscan(™) esophageal high-resolution manometry system. Neurogastroenterol Motil 2015 Feb;27(2):277-84 PMID: 25545126 PMCID: PMC4437530

Pubmed ID



BACKGROUND: Manoscan(™) is one of the commonly used high-resolution manometry (HRM) systems with declared measurement accuracy of 1-2 mmHg. However, the accuracy of pressure measurements is limited by development of pressure drift (PD) throughout recording. To date, there has been no systematic investigation to identify the factors contributing to PD. The aim of the present study was to characterize the frequency and magnitude of PD in Manoscan(™) system and identify the factors contributing to PD.

METHODS: Records of 560 consecutive clinical esophageal HRM studies recorded by six distinct HRM catheters were retrospectively reviewed. PD was defined as the residual pressure measurement by each sensor immediately after removal of the catheter. Non-parametric locally weighted regression analysis was performed to assess the effect of duration of study, number of prior uses of a catheter, peak and average pressure exposure during a study on the PD.

KEY RESULTS: The majority (95%) of clinical manometry studies showed a non-negligible PD of more than 5 mmHg. The overall PD was 13 ± 5 mmHg and the sensor with greatest amount of PD showed 23 ± 12 mmHg of drift. The upper esophageal sphincter showed the highest PD. Average pressure exposure of a sensor throughout the recording was the most important predictor of PD. PD inversely correlated with number of prior uses of a catheter.

CONCLUSIONS & INFERENCES: The PD preferentially affects esophageal high-pressure zones, and strongly correlates with 'average pressure exposure' of a sensor during manometry. Available algorithms of the analysis software do not adequately correct the PD.

Author List

Babaei A, Lin EC, Szabo A, Massey BT


Benson T. Massey MD Professor in the Medicine department at Medical College of Wisconsin
Aniko Szabo PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin


2-s2.0-84921444128   13 Citations

MESH terms used to index this publication - Major topics in bold

Esophageal Motility Disorders
Esophageal Sphincter, Upper
Image Interpretation, Computer-Assisted
Retrospective Studies
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6