Faculty Collaboration Database

Transcriptional regulation by HMGN proteins. Biochim Biophys Acta 2010 Jan-Feb;1799(1-2):74-9

Date

02/04/2010

Pubmed ID

20123070

Pubmed Central ID

PMC2818479

DOI

10.1016/j.bbagrm.2009.11.006

Abstract

High mobility group nucleosomal proteins (HMGNs) are small non-histone proteins associated with chromatin. HMGNs have the unique ability to bind to nucleosomes with higher affinity than to naked DNA [1]. They have been studied extensively for their ability to modulate transcription. Although initially viewed as general transcriptional activators on chromatin templates, it is now appreciated that they are instead highly specific modulators of gene expression. We review the mechanisms for targeting HMGNs to specific genes and for how they subsequently regulate transcription.

Author List

Zhu N, Hansen U

Author

Nan Zhu PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Chromatin
Gene Expression Regulation
HMGN Proteins
Humans
Protein Processing, Post-Translational
Trans-Activators
Transcription, Genetic