Transcriptional regulation by HMGN proteins. Biochim Biophys Acta 2010;1799(1-2):74-9
Date
02/04/2010Pubmed ID
20123070Pubmed Central ID
PMC2818479DOI
10.1016/j.bbagrm.2009.11.006Scopus ID
2-s2.0-74549214344 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
High mobility group nucleosomal proteins (HMGNs) are small non-histone proteins associated with chromatin. HMGNs have the unique ability to bind to nucleosomes with higher affinity than to naked DNA [1]. They have been studied extensively for their ability to modulate transcription. Although initially viewed as general transcriptional activators on chromatin templates, it is now appreciated that they are instead highly specific modulators of gene expression. We review the mechanisms for targeting HMGNs to specific genes and for how they subsequently regulate transcription.
Author List
Zhu N, Hansen UMESH terms used to index this publication - Major topics in bold
AnimalsChromatin
Gene Expression Regulation
HMGN Proteins
Humans
Protein Processing, Post-Translational
Trans-Activators
Transcription, Genetic
