The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process. Virchows Arch 2014 Jul;465(1):89-96
Date
05/20/2014Pubmed ID
24838683DOI
10.1007/s00428-014-1591-9Scopus ID
2-s2.0-84904747139 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
Some renal epithelial neoplasms, such as renal angiomyoadenomatous tumor, clear cell papillary renal cell carcinoma and renal cell carcinoma with smooth muscle stroma, contain a variably prominent smooth muscle stromal component. Whether or not this leiomyomatous stroma is part of the neoplastic proliferation has not been firmly established. We studied the clonality status of 14 renal cell carcinomas with a prominent smooth muscle stromal component (four renal angiomyoadenomatous tumors/clear cell papillary carcinomas, five clear cell carcinomas, two papillary carcinomas, and three renal cell carcinomas with smooth muscle rich stroma) using the human androgen receptor assay (HUMARA). We found the leiomyomatous stromal component in all analyzable (8/14) cases to be polyclonal and therefore reactive rather than neoplastic. Based on morphological observations, we propose that the non-neoplastic leiomyomatous stromal component is likely derived from smooth muscle cells of large caliber veins located at the peripheral capsular region or within the collagenous septae of the tumors.
Author List
Petersson F, Branzovsky J, Martinek P, Korabecna M, Kruslin B, Hora M, Peckova K, Bauleth K, Pivovarcikova K, Michal M, Svajdler M, Sperga M, Bulimbasic S, Leroy X, Rychly B, Trivunic S, Kokoskova B, Rotterova P, Podhola M, Suster S, Hes OMESH terms used to index this publication - Major topics in bold
Adenocarcinoma, Clear CellAdenocarcinoma, Papillary
Adult
Aged
Aged, 80 and over
Carcinoma, Papillary
Carcinoma, Renal Cell
Clone Cells
Female
Humans
Immunohistochemistry
Kidney Neoplasms
Leiomyoma
Middle Aged
Muscle, Smooth
Receptors, Androgen