Faculty Collaboration Database

Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach. Biol Blood Marrow Transplant 2015 Dec;21(12):2061-2068

Date

09/04/2015

Pubmed ID

26327628

Pubmed Central ID

PMC4639405

DOI

10.1016/j.bbmt.2015.08.030

Scopus ID

2-s2.0-84947416879 (requires institutional sign-in at Scopus site)   80 Citations

Abstract

Engraftment syndrome (ES) encompasses a continuum of periengraftment complications after autologous hematopoietic stem cell transplantation. ES may include noninfectious fever, skin rash, diarrhea, hepatic dysfunction, renal dysfunction, transient encephalopathy, and capillary leak features, such as noncardiogenic pulmonary infiltrates, hypoxia, and weight gain with no alternative etiologic basis other than engraftment. Given its pleiotropic clinical presentation, the transplant field has struggled to clearly define ES and related syndromes. Here, we present a comprehensive review of ES in all documented disease settings. Furthermore, we discuss the proposed risk factors, etiology, and clinical relevance of ES. Finally, our current approach to ES is included along with a proposed treatment algorithm for the management of this complication.

Author List

Cornell RF, Hari P, Drobyski WR

Authors

William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin
Parameswaran Hari MD Adjunct Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Brain Diseases
Capillary Leak Syndrome
Diarrhea
Exanthema
Fever
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Hepatic Insufficiency
Humans
Immunosuppressive Agents
Lymphoma
Multiple Myeloma
POEMS Syndrome
Renal Insufficiency
Risk Factors
Transplantation Conditioning
Transplantation, Autologous