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Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach. Biol Blood Marrow Transplant 2015 Dec;21(12):2061-2068 PMID: 26327628 PMCID: PMC4639405

Pubmed ID



Engraftment syndrome (ES) encompasses a continuum of periengraftment complications after autologous hematopoietic stem cell transplantation. ES may include noninfectious fever, skin rash, diarrhea, hepatic dysfunction, renal dysfunction, transient encephalopathy, and capillary leak features, such as noncardiogenic pulmonary infiltrates, hypoxia, and weight gain with no alternative etiologic basis other than engraftment. Given its pleiotropic clinical presentation, the transplant field has struggled to clearly define ES and related syndromes. Here, we present a comprehensive review of ES in all documented disease settings. Furthermore, we discuss the proposed risk factors, etiology, and clinical relevance of ES. Finally, our current approach to ES is included along with a proposed treatment algorithm for the management of this complication.

Author List

Cornell RF, Hari P, Drobyski WR


William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin
Parameswaran Hari MD Chief, Professor in the Medicine department at Medical College of Wisconsin


2-s2.0-84947416879   10 Citations

MESH terms used to index this publication - Major topics in bold

Brain Diseases
Capillary Leak Syndrome
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Hepatic Insufficiency
Immunosuppressive Agents
Multiple Myeloma
POEMS Syndrome
Renal Insufficiency
Risk Factors
Transplantation Conditioning
Transplantation, Autologous
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6