Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Mol Cell Neurosci 2007 Nov;36(3):416-24
Date
09/25/2007Pubmed ID
17889554DOI
10.1016/j.mcn.2007.08.002Scopus ID
2-s2.0-35449001021 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Tissue damage in the CNS is critically influenced by the adaptive immune system. Primary oligodendrocyte damage (by overexpression of PLP) leads to low-grade inflammation of high pathological impact, which is mediated by CD8+ T cells. To yield further insight into pathogenesis and nature of immune responses in myelin mutated mice, we here apply a detailed immunological characterization of CD8+ T cells in PLP-transgenic and aged wild type mice. We provide evidence that T effector cells accumulate in the CNS of PLP-transgenic and wild-type mice and show a higher level of activation in mutant mice, indicated by surface markers and clonal expansions, as demonstrated by T cell receptor CDR3-spectratype analysis. Vbeta-Jbeta similarities suggest specificity against a common antigen, albeit we could not find specific responses against myelin-antigen-derived peptides. The association of primary oligodendrocyte damage with secondary expansions of pathogenic cells underlines the role of adaptive immune reactions in neurodegenerative and neuroinflammatory diseases.
Author List
Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmair K, Martini R, Wiendl HAuthor
Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutoimmunity
CD8 Antigens
CD8-Positive T-Lymphocytes
Cell Proliferation
Central Nervous System
Clone Cells
Demyelinating Diseases
Immune System
Immunity, Innate
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Mice, Transgenic
Myelin Sheath
Oligodendroglia
T-Lymphocyte Subsets
