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Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis. J Mol Med (Berl) 2005 Oct;83(10):806-11

Date

07/16/2005

Pubmed ID

16021520

DOI

10.1007/s00109-005-0661-5

Scopus ID

2-s2.0-26044436485 (requires institutional sign-in at Scopus site)   60 Citations

Abstract

Uncoupling protein 2 (UCP2) is a member of the mitochondrial proton transport family that uncouples proton entry to the mitochondria from ATP synthesis. UCP2 expression levels have been linked to predisposition to diabetes and obesity. In addition, UCP2 prevents neuronal death and injury. Here we show that the common -866G/A promoter polymorphism is associated with susceptibility to multiple sclerosis (MS) in the German population. We analysed altogether 1,097 MS patients and 462 control subjects from two cohorts and found that the common G allele is associated with disease susceptibility (p = 0.0015). The UCP2 -866G allele is correlated with lower levels of UCP2 expression as shown here in vitro and in vivo. Thus, UCP2 promoter polymorphism may contribute to MS susceptibility by regulating the level of UCP2 protein in the central nervous and/or the immune systems.

Author List

Vogler S, Goedde R, Miterski B, Gold R, Kroner A, Koczan D, Zettl UK, Rieckmann P, Epplen JT, Ibrahim SM

Author

Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Alleles
Cells, Cultured
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Ion Channels
Male
Membrane Transport Proteins
Middle Aged
Mitochondrial Proteins
Monocytes
Multiple Sclerosis
Polymorphism, Genetic
Promoter Regions, Genetic
T-Lymphocytes
Uncoupling Protein 2