Medical College of Wisconsin
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Multicenter prospective study of ulcerated hemangiomas. J Pediatr 2007 Dec;151(6):684-9, 689.e1 PMID: 18035154

Pubmed ID



OBJECTIVE: To identify clinical features of infants with ulcerated infantile hemangiomas.

STUDY DESIGN: Cross-sectional analysis was conducted within a prospective cohort study of children with infantile hemangiomas. Children younger than 12 years of age were recruited. Demographic and prenatal/perinatal information was collected. Hemangioma size, location, subtype, course, complications, and treatments were recorded.

RESULTS: One thousand ninety-six patients were enrolled, and 173 (15.8%) patients experienced ulceration. Ulceration occurred in 192 (9.8%) of 1960 [corrected] total hemangiomas. Hemangiomas with ulcerations were more likely large, mixed clinical type, segmental morphologic type, and located on the lower lip, neck, or anogenital region. Ulceration occurred at a median age of 4 months, most often during the proliferative phase. Children with ulcerated hemangiomas were more likely to present to a pediatric dermatologist at a younger age and to require treatment. Bleeding occurred in 41% of ulcerated lesions but was rarely of clinical significance. Infection occurred in 16%.

CONCLUSIONS: Ulceration occurs in nearly 16% of patients with infantile hemangiomas, most often by 4 months of age, during the proliferative phase. Location, size, and clinical and morphologic type are associated with an increased risk for development of ulceration.

Author List

Chamlin SL, Haggstrom AN, Drolet BA, Baselga E, Frieden IJ, Garzon MC, Horii KA, Lucky AW, Metry DW, Newell B, Nopper AJ, Mancini AJ


2-s2.0-36148949008   124 Citations

MESH terms used to index this publication - Major topics in bold

Child, Preschool
Cross-Sectional Studies
Multivariate Analysis
Prospective Studies
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70