Heroin-induced neuronal activation in rat brain assessed by functional MRI. Neuroreport 2000 Apr 07;11(5):1085-92
Date
05/03/2000Pubmed ID
10790887DOI
10.1097/00001756-200004070-00036Scopus ID
2-s2.0-0000323294 (requires institutional sign-in at Scopus site) 51 CitationsAbstract
The present study demonstrates the application of fMRI technology to neuropharmacology and the interaction of drug/receptor in the rat brain. Specifically, we have observed two different types of fMRI signal changes induced by acute i.v. heroin administration in rat brains under conditions of spontaneous and artificial respiration. Under spontaneous respiration, a global decrease in fMRI signal was observed; under artificial respiration, a region-specific increase in fMRI signal was identified and the activation sites are consistent with the distribution of opiate mu-receptors in rat brain as previously reported by autoradiography. Both heroin-induced fMRI signal changes were suppressed by pretreatment of naloxone, an opiate mu-receptor antagonist, and reversed by injection of naloxone following heroin infusion. These results suggest that fMRI has specific advantages in spatial and temporal resolution for studies of neuropharmacology and drugs of abuse.
Author List
Xu H, Li SJ, Bodurka J, Zhao X, Xi ZX, Stein EAMESH terms used to index this publication - Major topics in bold
Analgesics, OpioidAnimals
Blood Pressure
Brain
Brain Mapping
Energy Metabolism
Heroin
Heroin Dependence
Linear Models
Magnetic Resonance Imaging
Male
Naloxone
Narcotic Antagonists
Neurons
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu
