Faculty Collaboration Database

Contrast enhanced MR venography with gadofosveset trisodium: evaluation of the intracranial and extracranial venous system. J Magn Reson Imaging 2014 Sep;40(3):630-40

Date

11/26/2013

Pubmed ID

24273083

DOI

10.1002/jmri.24409

Scopus ID

2-s2.0-84906084714 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

PURPOSE: To demonstrate the efficacy of contrast enhanced magnetic resonance venography (CEMRV) using gadofosveset trisodium in the comprehensive evaluation of the intracranial and extracranial venous system.

MATERIALS AND METHODS: Temporal signal decay, in-plane saturation and flow artifacts were assessed in an institutional review board approved, HIPAA compliant CEMRV study of 99 subjects. In a 39 subject subset, percent diameter narrowing of the internal jugular (IJ), brachiocephalic and azygous veins were coded according to the following ordinal grades for both catheter venography (CV) and CEMRV: grade 0 ≤ 50%, grade 1 >50% and ≤ 75%, grade 2 >75% and <100% and grade 3 = 100% and compared with pressure gradient measurements obtained during CV.

RESULTS: There was no significant signal decay, in-plane saturation or flow artifacts identified on CEMRV or hemodynamically significant pressure gradients identified on CV. All brachiocephalic and azygous veins had matched grade 0 narrowing on both modalities. Discrepancy between modalities occurred in the IJ veins at the level of thyroid gland where 15% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 4% for CV or below the thyroid gland where 5% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 20% for CV. There was fair agreement (κ = 0.24) between modalities for grade of narrowing in the combined data set of all coded veins.

CONCLUSION: CEMRV using gadofosveset trisodium is accurate in the evaluation of the venous system.

Author List

Kramer LA, Cohen AM, Hasan KM, Heimbigner JH, Barreto AD, Brod SA, Narayana PA, Wolinsky JS

MESH terms used to index this publication - Major topics in bold

Adult
Artifacts
Cerebrovascular Circulation
Contrast Media
Female
Gadolinium
Humans
Magnetic Resonance Angiography
Male
Middle Aged
Multiple Sclerosis
Organometallic Compounds
Prospective Studies
Sensitivity and Specificity
Veins