Faculty Collaboration Database

A contemporary review of paediatric heart transplantation and mechanical circulatory support. Cardiol Young 2016 Jun;26(5):851-9

Date

03/17/2016

Pubmed ID

26979140

DOI

10.1017/S1047951116000184

Scopus ID

2-s2.0-84961200653 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Improvements in the care of children with cardiomyopathy, CHDs, and acquired heart disease have led to an increased number of children surviving with advanced heart failure. In addition, the advent of more durable mechanical circulatory support options in children has changed the outcome for many patients who otherwise would have succumbed while waiting for heart transplantation. As a result, more children with end-stage heart failure are being referred for heart transplantation, and there is increased demand for a limited donor organ supply. A review of important publications in the recent years related to paediatric heart failure, transplantation, and mechanical circulatory support show a trend towards pushing the limits of the current therapies to address the needs of this growing population. There have been a number of publications focussing on previously published risk factors perceived as barriers to successful heart transplantation, including elevated pulmonary vascular resistance, medication non-adherence, re-transplantation, transplantation of the failed Fontan patient, and transplantation in an infant or child bridged with mechanical circulatory support. This review will highlight some of these key articles from the last 3 years and describe recent advances in the understanding, diagnosis, and management of children with end-stage heart disease.

Author List

Kindel SJ, Everitt MD

Author

Steven J. Kindel MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cardiomyopathies
Child
Extracorporeal Membrane Oxygenation
Heart Failure
Heart Transplantation
Heart-Assist Devices
Humans
Medication Adherence
Pediatrics
Risk Factors
Treatment Outcome
Waiting Lists