Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Sleep deprivation in the rat: VI. Skin changes. Sleep 1989 Feb;12(1):42-6 PMID: 2928624

Abstract

All rats subjected to total or paradoxical sleep deprivation by the disk apparatus developed severe ulcerative and hyperkeratotic skin lesions localized to the plantar surfaces of their paws and to their tails. Yoked control rats only occasionally developed similar appearing lesions, which were always much less severe than in deprived rats. The deprived rat lesions could not be explained by pressure, disk rotation, water immersion, infection, necrotizing vasculitis, tyrosinemia, protein deficiency, or reduced rates of mitosis. Thus, although paw and tail lesions constitute a very reliable and severe symptom of total or selective sleep deprivation in the rat that potentially could yield insights into the pathogenic mechanisms induced by sleep loss, the mediation of the lesions remains unknown.

Author List

Kushida CA, Everson CA, Suthipinittharm P, Sloan J, Soltani K, Bartnicke B, Bergmann BM, Rechtschaffen A

Author

Carol A. Everson PhD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Arousal
Cerebral Cortex
Electroencephalography
Male
Mitosis
Necrosis
Rats
Rats, Inbred Strains
Skin
Sleep Deprivation
Sleep Stages
Sleep, REM



View this publication's entry at the Pubmed website PMID: 2928624
jenkins-FCD Prod-141 f776ee82366dc5656a368d51cce32734d2f9b9a0