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The Impact of Cardiac Motion on Aortic Valve Flow Used in Computational Simulations of the Thoracic Aorta. J Biomech Eng 2016 09 01;138(9)

Date

07/02/2016

Pubmed ID

27367143

Pubmed Central ID

PMC4967883

DOI

10.1115/1.4033964

Scopus ID

2-s2.0-84978765764

Abstract

Advancements in image-based computational modeling are producing increasingly more realistic representations of vasculature and hemodynamics, but so far have not compensated for cardiac motion when imposing inflow boundary conditions. The effect of cardiac motion on aortic flow is important when assessing sequelae in this region including coarctation of the aorta (CoA) or regurgitant fraction. The objective of this investigation was to develop a method to assess and correct for the influence of cardiac motion on blood flow measurements through the aortic valve (AoV) and to determine its impact on patient-specific local hemodynamics quantified by computational fluid dynamics (CFD). A motion-compensated inflow waveform was imposed into the CFD model of a patient with repaired CoA that accounted for the distance traveled by the basal plane during the cardiac cycle. Time-averaged wall shear stress (TAWSS) and turbulent kinetic energy (TKE) values were compared with CFD results of the same patient using the original waveform. Cardiac motion resulted in underestimation of flow during systole and overestimation during diastole. Influences of inflow waveforms on TAWSS were greatest along the outer wall of the ascending aorta (AscAo) (∼30 dyn/cm2). Differences in TAWSS were more pronounced than those from the model creation or mesh dependence aspects of CFD. TKE was slightly higher for the motion-compensated waveform throughout the aortic arch. These results suggest that accounting for cardiac motion when quantifying blood flow through the AoV can lead to different conclusions for hemodynamic indices, which may be important if these results are ultimately used to predict patient outcomes.

Author List

Wendell DC, Samyn MM, Cava JR, Krolikowski MM, LaDisa JF Jr

Authors

Joseph R. Cava MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
John LaDisa PhD Assistant Professor in the Biomedical Engineering department at Marquette University
Margaret Mary Samyn MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Aorta, Thoracic
Aortic Coarctation
Aortic Valve
Blood Flow Velocity
Blood Pressure
Computer Simulation
Female
Humans
Hydrodynamics
Models, Cardiovascular
Movement
Shear Strength
Stress, Mechanical
Viscosity
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc