Associations between regional brain physiology and trait impulsivity, motor inhibition, and impaired control over drinking. Psychiatry Res 2015 Aug 30;233(2):81-7
Date
06/13/2015Pubmed ID
26065376Pubmed Central ID
PMC4536192DOI
10.1016/j.pscychresns.2015.04.010Scopus ID
2-s2.0-84938748914 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Trait impulsivity and poor inhibitory control are well-established risk factors for alcohol misuse, yet little is known about the associated neurobiological endophenotypes. Here we examined correlations among brain physiology and self-reported trait impulsive behavior, impaired control over drinking, and a behavioral measure of response inhibition. A sample of healthy drinkers (n = 117) completed a pulsed arterial spin labeling (PASL) scan to quantify resting regional cerebral blood flow (rCBF), as well as measures of self-reported impulsivity (Eysenck I7 Impulsivity scale) and impaired control over drinking. A subset of subjects (n = 40) performed a stop signal task during blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging to assess brain regions involved in response inhibition. Eysenck I7 scores were inversely related to blood flow in the right precentral gyrus. Significant BOLD activation during response inhibition occurred in an overlapping right frontal motor/premotor region. Moreover, impaired control over drinking was associated with reduced BOLD response in the same region. These findings suggest that impulsive personality and impaired control over drinking are associated with brain physiology in areas implicated in response inhibition. This is consistent with the idea that difficulty controlling behavior is due in part to impairment in motor restraint systems.
Author List
Weafer J, Dzemidzic M, Eiler W 2nd, Oberlin BG, Wang Y, Kareken DAAuthor
Yang Wang MD Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAlcohol Drinking
Alcoholism
Brain Mapping
Female
Humans
Impulsive Behavior
Magnetic Resonance Imaging
Male
Motor Cortex
Personality
Self-Control
Young Adult
