Thrombotic thrombocytopenic purpura precipitated by thyrotoxicosis. J Clin Apher 2012 Nov;27(5):265-6
Date
05/31/2012Pubmed ID
22644892DOI
10.1002/jca.21210Scopus ID
2-s2.0-84867233715 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Thrombotic thrombocytopenic purpura (TTP) may be seen in association with autoimmune disorders such as immune hemolytic anemia and systemic lupus erythematosus, but rarely has it been associated with Graves' disease. We report one such case of a woman with new-onset thyrotoxicosis caused by Graves' disease, who abruptly developed TTP, confirmed by low serum ADAMTS-13 value. She had a dramatic response to plasma exchange, with remission of TTP. Definitive treatment with radioactive iodine resulted in euthyroidism and has prevented recurrence of TTP.
Author List
Chhabra S, Tenorio GMESH terms used to index this publication - Major topics in bold
ADAM ProteinsADAMTS13 Protein
Aged
Atrial Fibrillation
Autoimmunity
Female
Graves Disease
Humans
Plasma Exchange
Purpura, Thrombotic Thrombocytopenic
Thyrotoxicosis
Treatment Outcome
