Faculty Collaboration Database

Pulmonary Vein Doppler Patterns in Infants with Single Right Ventricle Anomalies After Initial Staged Palliations. Pediatr Cardiol 2017 Aug;38(6):1288-1295

Date

06/21/2017

Pubmed ID

28631208

DOI

10.1007/s00246-017-1660-3

Scopus ID

2-s2.0-85021174639 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

The aim of this study was to describe serial changes in echocardiographic Doppler pulmonary vein flow (PVF) patterns in infants with single right ventricle (RV) anomalies enrolled in the Single Ventricle Reconstruction trial. Measurement of PVF peak systolic (S) and diastolic (D) velocities, velocity time integrals (VTI), S/D peak velocity and VTI ratios, and frequency of atrial reversal (Ar) waves were made at three postoperative time points in 261 infants: early post-Norwood, pre-stage II surgery, and 14 months. Indices were compared over time, between initial shunt type [modified Blalock-Taussig shunt (MBTS) and right ventricle-to-pulmonary artery shunt (RVPAS)] and in relation to clinical outcomes. S velocities and VTI increased over time while D wave was stable, resulting in increasing S/D peak velocity and VTI ratios, with a median post-Norwood S/D VTI ratio of 1.14 versus 1.38 at pre-stage II and 1.89 at 14 months (P < 0.0001 between intervals). MBTS subjects had significantly higher S/D peak velocity and VTI ratios compared to RVPAS at the post-Norwood and pre-stage II time points (P < 0.0001) but not by 14 months. PVF patterns did not correlate with survival or hospitalization course at 1 year. PVF patterns after Norwood palliation differ from normal infants by having a dominant systolic pattern throughout infancy. PVF differences based upon shunt type resolve by 14 months and did not correlate with clinical outcomes. This study describes normative values and variations in PVF for infants with a single RV from shunt-dependent pulmonary blood flow to cavopulmonary blood flow.

Author List

Kirkpatrick EC, Steltzer J, Simpson P, Pan A, Dragulescu A, Falkensammer CB, Gelehrter S, Lai WW, Levine J, Miller S, Miller TA, Pruetz J, Sachdeva R, Thacker D, Frommelt P

Authors

Peter C. Frommelt MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
Edward C. Kirkpatrick DO Professor in the Pediatrics department at Medical College of Wisconsin
Amy Y. Pan PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anastomosis, Surgical
Blalock-Taussig Procedure
Cardiovascular Surgical Procedures
Echocardiography, Doppler
Heart Defects, Congenital
Heart Ventricles
Humans
Infant
Norwood Procedures
Palliative Care
Pulmonary Artery
Pulmonary Veins
Regional Blood Flow
Retrospective Studies