Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Recent advances in understanding multiple myeloma. Hematol Oncol Stem Cell Ther 2017 Jun 13 PMID: 28633036

Abstract

There have been major recent advancements in the understanding and management of multiple myeloma which in turn has led to unprecedented survival outcomes for patients. Diagnostic and response criteria have been recently revised. Our understanding of clonal progression, evolution, and clonal tides will inform therapeutic choices and appropriate treatment for patients. Response rates to initial induction with modern triplet therapies containing proteasome inhibitors and immunomodulators have made this approach the global standard for initial treatment. Although the relevance of autologous transplantation has been questioned in the setting of modern induction therapy, we have new data suggesting its continued relevance. Recent studies performed in the context of novel agent induction suggest that autologous transplantation continues to improve response rates and progression-free survival, thus underscoring its role in transplant-eligible patients. Emerging paradigms in the treatment of multiple myeloma include immune approaches, such as adoptive cellular therapies, vaccines, or antibody-based immune manipulations, all of which seem to synergize with a transplant platform. Allogeneic transplantation is limited in scope by the concern of prohibitive toxicity and is applicable mainly to younger patients with high-risk disease. However, the allogeneic approach offers even more options of immunotherapy at relapse, including donor lymphocyte infusions, immunomodulatory drug maintenance, and withdrawal of immune suppression.

Author List

Hari P

Author

Parameswaran Hari MD Interim Chief, Professor in the Medicine department at Medical College of Wisconsin



View this publication's entry at the Pubmed website PMID: 28633036
jenkins-FCD Prod-122 cd2d52783a48a4ccec26c8f4da41e571848a97a0