The Molecular Basis for Ca(2+) Signalling by NAADP: Two-Pore Channels in a Complex? Messenger (Los Angel) 2012 Jun 01;1(1):63-76 PMID: 25309835 PMCID: PMC4193953
Abstract
NAADP is a potent Ca(2+) mobilizing messenger in a variety of cells but its molecular mechanism of action is incompletely understood. Accumulating evidence indicates that the poorly characterized two-pore channels (TPCs) in animals are NAADP sensitive Ca(2+)-permeable channels. TPCs localize to the endo-lysosomal system but are functionally coupled to the better characterized endoplasmic reticulum Ca(2+) channels to generate physiologically relevant complex Ca(2+) signals. Whether TPCs directly bind NAADP is not clear. Here we discuss the idea based on recent studies that TPCs are the pore-forming subunits of a protein complex that includes tightly associated, low molecular weight NAADP-binding proteins.
Author List
Marchant JS, Lin-Moshier Y, Walseth TF, Patel SAuthor
Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinView this publication's entry at the Pubmed website PMID: 25309835
