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The Molecular Basis for CaSignalling by NAADP: Two-Pore Channels in a Complex? Messenger (Los Angel) 2012 Jun 01;1(1):63-76 PMID: 25309835 PMCID: PMC4193953


NAADP is a potent Camobilizing messenger in a variety of cells but its molecular mechanism of action is incompletely understood. Accumulating evidence indicates that the poorly characterized two-pore channels (TPCs) in animals are NAADP sensitive Ca-permeable channels. TPCs localize to the endo-lysosomal system but are functionally coupled to the better characterized endoplasmic reticulum Cachannels to generate physiologically relevant complex Casignals. Whether TPCs directly bind NAADP is not clear. Here we discuss the idea based on recent studies that TPCs are the pore-forming subunits of a protein complex that includes tightly associated, low molecular weight NAADP-binding proteins.

Author List

Marchant JS, Lin-Moshier Y, Walseth TF, Patel S


Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

View this publication's entry at the Pubmed website PMID: 25309835
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