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Timing in cellular Ca2+ signaling. Curr Biol 2008 Sep 09;18(17):R769-R776 PMID: 18786382 PMCID: PMC3236564


Calcium (Ca2+) signals are generated across a broad time range. Kinetic considerations impact how information is processed to encode and decode Ca2+ signals, the choreography of responses that ensure specific and efficient signaling and the overall temporal amplification such that ephemeral Ca2+ signals have lasting physiological value. The reciprocal importance of timing for Ca2+ signaling, and Ca2+ signaling for timing is exemplified by the altered kinetic profiles of Ca2+ signals in certain diseases and the likely role of basal Ca2+ fluctuations in the perception of time itself.

Author List

Boulware MJ, Marchant JS


Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Calcium Signaling
Feedback, Physiological
Models, Biological
Time Factors

View this publication's entry at the Pubmed website PMID: 18786382
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