Timing in cellular Ca2+ signaling. Curr Biol 2008 Sep 09;18(17):R769-R776
Date
09/13/2008Pubmed ID
18786382Pubmed Central ID
PMC3236564DOI
10.1016/j.cub.2008.07.018Scopus ID
2-s2.0-50849084152 (requires institutional sign-in at Scopus site) 49 CitationsAbstract
Calcium (Ca2+) signals are generated across a broad time range. Kinetic considerations impact how information is processed to encode and decode Ca2+ signals, the choreography of responses that ensure specific and efficient signaling and the overall temporal amplification such that ephemeral Ca2+ signals have lasting physiological value. The reciprocal importance of timing for Ca2+ signaling, and Ca2+ signaling for timing is exemplified by the altered kinetic profiles of Ca2+ signals in certain diseases and the likely role of basal Ca2+ fluctuations in the perception of time itself.
Author List
Boulware MJ, Marchant JSAuthor
Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CalciumCalcium Signaling
Feedback, Physiological
Kinetics
Models, Biological
Time Factors
