Postnatal changes in the expression of serotonin 2A receptors in various brain stem nuclei of the rat. J Appl Physiol (1985) 2008 Jun;104(6):1801-8
Date
04/19/2008Pubmed ID
18420721Pubmed Central ID
PMC3694347DOI
10.1152/japplphysiol.00057.2008Scopus ID
2-s2.0-49649105520 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
Previously, we reported a critical period [around postnatal day (P) 12-13 in the rat] in respiratory network development when distinct neurochemical, metabolic, and physiological changes occur. Since serotonin 2A (5-HT(2A)) receptors play an important role in respiratory modulation, we hypothesized that they may undergo developmental adjustments during the critical period. Semi-quantitative immunohistochemical analyses were conducted in labeled neurons in a number of brain stem nuclei with or without known respiratory functions from P2 to P21 in rats. Our data indicate that the expressions of 5-HT(2A) receptors in neurons of the pre-Bötzinger complex, the nucleus ambiguus, and the hypoglossal nucleus were maintained within a relatively narrow range between P2 and P21, with a dip at P3-P4 and a significant reduction only at P12. This change was not observed in the nonrespiratory cuneate nucleus. These results suggest that reduced expressions of 5-HT(2A) receptors at P12 contributes to neurochemical imbalance within brain stem respiratory nuclei at that time and may be involved in decreased hypoxic ventilatory response at this critical period of development.
Author List
Liu Q, Wong-Riley MTMESH terms used to index this publication - Major topics in bold
Age FactorsAnimals
Animals, Newborn
Brain Stem
Immunohistochemistry
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2A
Respiratory Center