Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Borrelia burgdorferi and its tropisms for adhesion molecules in the joint. Curr Opin Rheumatol 2002 Jul;14(4):394-8

Date

07/16/2002

Pubmed ID

12118173

DOI

10.1097/00002281-200207000-00010

Abstract

Borrelia burgdorferi, the spirochete that causes Lyme disease, has evolved elegant strategies for interacting with its mammalian hosts. Among them are several distinct mechanisms of adhesion to cells and extracellular matrix components. The mammalian receptors for B. burgdorferi that have been most thoroughly studied, and for which candidate bacterial ligands have been identified, are decorin, fibronectin, glycosaminoglycans, and beta3-chain integrins. This diversity of adhesion mechanisms allows B. burgdorferi to infect multiple tissues, including the synovial tissues of the joints.

Author List

Coburn J, Medrano M, Cugini C

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Arthritis, Infectious
Bacterial Adhesion
Borrelia burgdorferi
Cell Adhesion Molecules
Extracellular Matrix Proteins
Joints
Lyme Disease
Synovial Membrane
Tropism
jenkins-FCD Prod-409 d1e206b0be345926047b0d9c353c78a4cce4058b