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Borrelia burgdorferi and its tropisms for adhesion molecules in the joint. Curr Opin Rheumatol 2002 Jul;14(4):394-8 PMID: 12118173

Pubmed ID



Borrelia burgdorferi, the spirochete that causes Lyme disease, has evolved elegant strategies for interacting with its mammalian hosts. Among them are several distinct mechanisms of adhesion to cells and extracellular matrix components. The mammalian receptors for B. burgdorferi that have been most thoroughly studied, and for which candidate bacterial ligands have been identified, are decorin, fibronectin, glycosaminoglycans, and beta3-chain integrins. This diversity of adhesion mechanisms allows B. burgdorferi to infect multiple tissues, including the synovial tissues of the joints.

Author List

Coburn J, Medrano M, Cugini C


Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin


2-s2.0-0035985830   16 Citations

MESH terms used to index this publication - Major topics in bold

Arthritis, Infectious
Bacterial Adhesion
Borrelia burgdorferi
Cell Adhesion Molecules
Extracellular Matrix Proteins
Lyme Disease
Synovial Membrane
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70