Borrelia burgdorferi and its tropisms for adhesion molecules in the joint. Curr Opin Rheumatol 2002 Jul;14(4):394-8
Date
07/16/2002Pubmed ID
12118173DOI
10.1097/00002281-200207000-00010Scopus ID
2-s2.0-0035985830 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Borrelia burgdorferi, the spirochete that causes Lyme disease, has evolved elegant strategies for interacting with its mammalian hosts. Among them are several distinct mechanisms of adhesion to cells and extracellular matrix components. The mammalian receptors for B. burgdorferi that have been most thoroughly studied, and for which candidate bacterial ligands have been identified, are decorin, fibronectin, glycosaminoglycans, and beta3-chain integrins. This diversity of adhesion mechanisms allows B. burgdorferi to infect multiple tissues, including the synovial tissues of the joints.
Author List
Coburn J, Medrano M, Cugini CAuthor
Jenifer Coburn PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Arthritis, InfectiousBacterial Adhesion
Borrelia burgdorferi
Cell Adhesion Molecules
Extracellular Matrix Proteins
Joints
Lyme Disease
Synovial Membrane
Tropism
