Faculty Collaboration Database

Evolution of the AMP-forming acetyl-CoA synthetase gene in the Drosophilidae family. J Mol Evol 2003;57 Suppl 1:S297-303

Date

03/11/2004

Pubmed ID

15008428

DOI

10.1007/s00239-003-0040-1

Scopus ID

2-s2.0-0348011471 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Analysis of the AMP-forming ACS gene was performed in 12 species of the Drosophilidae family. Systematically four introns, aligned at the same positions, were detected, but none of them showed a position similar to those known for species outside the Drosophilidae family. The average length of introns varied from 63 to 75 bp but in two species Drosophila takahashii and D. kikkawai the length of the second intron was 343 and 210 bp, respectively. In coding regions, about 80% of the third codon positions were substituted while first and second positions showed, respectively, 14% and 6% substitutions. Interestingly, the divergence observed at the protein level between species was very low. The phylogenetic tree based on the DNA sequences of the exons was mainly in agreement with taxonomic classification and previous molecular phylogenies except for D. ananassae, which appeared more closely related to D. subobscura and D. funebris than to the species of the melanogaster group.

Author List

Karan D, Lesbats M, David JR, Capy P

Author

Dev Karan PhD Associate Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acetate-CoA Ligase
Adenosine Monophosphate
Amino Acid Sequence
Animals
Base Sequence
Drosophilidae
Evolution, Molecular
Genetic Variation
Introns
Molecular Sequence Data
Phylogeny
Polymorphism, Genetic
Sequence Homology, Nucleic Acid