Design and validation of a novel ferromagnetic bare metal stent capable of capturing and retaining endothelial cells. Ann Biomed Eng 2014 Dec;42(12):2416-24 PMID: 25138164
Pubmed ID
25138164DOI
10.1007/s10439-014-1088-3Abstract
Rapid healing of vascular stents is important for avoiding complications associated with stent thrombosis, restenosis, and bleeding related to antiplatelet drugs. Magnetic forces can be used to capture iron-labeled endothelial cells immediately following stent implantation, thereby promoting healing. This strategy requires the development of a magnetic stent that is biocompatible and functional. We designed a stent from the weakly ferromagnetic 2205 stainless steel using finite element analysis. The final design exhibited a principal strain below the fracture limit of 30% during crimping and expansion. Ten stents were fabricated and validated experimentally for fracture resistance. Another 10 stents magnetized with a neodymium magnet showed a magnetic field in the range of 100-750 mG. The retained magnetism was sufficiently strong to capture magnetically-labeled endothelial cells on the stent surfaces during in vitro studies. Magnetically-labeled endothelial cell capture was also verified in vivo after 7 days following coronary implantation in 4 pigs using histological analysis. Images of the stented blood vessels showed uniform endothelium formation on the stent surfaces. In conclusion, we have designed a ferromagnetic bare metal stent from 2205 stainless steel that is functional, biocompatible, and able to capture and retain magnetically-labeled endothelial cells in order to promote rapid stent healing.
Author List
Uthamaraj S, Tefft BJ, Klabusay M, Hlinomaz O, Sandhu GS, Dragomir-Daescu DAuthor
Brandon J. Tefft PhD Assistant Professor in the Biomedical Engineering department at Medical College of WisconsinScopus
2-s2.0-84919428718 8 CitationsMESH terms used to index this publication - Major topics in bold
Angioplasty, Balloon, CoronaryAnimals
Coronary Vessels
Endothelial Cells
Equipment Design
Ferric Compounds
Magnetic Phenomena
Materials Testing
Metal Nanoparticles
Microscopy, Fluorescence
Neodymium
Stainless Steel
Stents
Swine
