Scaffolds for tissue engineering of cardiac valves. Acta Biomater 2014 Jul;10(7):2877-93
Date
03/29/2014Pubmed ID
24675108DOI
10.1016/j.actbio.2014.03.014Scopus ID
2-s2.0-84901798498 (requires institutional sign-in at Scopus site) 148 CitationsAbstract
Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.
Author List
Jana S, Tefft BJ, Spoon DB, Simari RDAuthor
Brandon J. Tefft PhD Associate Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Heart ValvesHumans
Tissue Engineering
