Faculty Collaboration Database

Scaffolds for tissue engineering of cardiac valves. Acta Biomater 2014 Jul;10(7):2877-93 PMID: 24675108

Pubmed ID

24675108

DOI

10.1016/j.actbio.2014.03.014

Abstract

Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

Author List

Jana S, Tefft BJ, Spoon DB, Simari RD

Author

Brandon J. Tefft PhD Assistant Professor in the Biomedical Engineering department at Medical College of Wisconsin

Scopus

2-s2.0-84901798498   72 Citations

MESH terms used to index this publication - Major topics in bold

Heart Valves
Humans
Tissue Engineering