Laboratory and clinical variables to predict outcome in hemolytic-uremic syndrome. Am J Dis Child 1988 Sep;142(9):961-4
Date
09/01/1988Pubmed ID
3414627DOI
10.1001/archpedi.1988.02150090059022Scopus ID
2-s2.0-0023783771 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
To develop a guide to the prognosis of children with hemolytic-uremic syndrome, we reviewed the medical records of 78 patients with this diagnosis seen at The Children's Hospital, Boston, from 1976 through 1986. Two outcome groups were defined as follows: a "good outcome" group, which contained 6 patients with no serious sequelae at hospital discharge, and a "bad outcome" group, which contained 12 patients who died, had chronic renal failure, or had central nervous system sequelae at hospital discharge. Differences between the two groups in routine laboratory tests available within 48 hours of admission were identified by bivariate analysis. Using serum calcium (less than or equal to 2 mmol/L) plus urine output (less than 0.4 mL/kg/h) over a 24-hour period as a test to predict outcome, we identified patients who died, had chronic renal failure, or had serious central nervous system sequelae, with 75% sensitivity, 98% specificity, and 90% positive predictive value.
Author List
Havens PL, O'Rourke PP, Hahn J, Higgins J, Walker AMMESH terms used to index this publication - Major topics in bold
AdolescentChild
Child, Preschool
Coma
Diagnostic Tests, Routine
Female
Hemolytic-Uremic Syndrome
Humans
Infant
Kidney Failure, Chronic
Male
Predictive Value of Tests
Prognosis
Retrospective Studies
Risk Factors
Seizures
