Sequential methotrexate, 5-fluorouracil, and calcium leucovorin in colorectal carcinoma. Am J Clin Oncol 1986 Aug;9(4):352-4
Date
08/01/1986Pubmed ID
3489407DOI
10.1097/00000421-198608000-00015Scopus ID
2-s2.0-0022495204 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Forty-four patients with locally recurrent or metastatic colorectal adenocarcinoma were treated with methotrexate (MTX) 100 mg/m2 i.v. followed 1 h later by 5-fluorouracil (5-FU) 600 mg/m2 i.v. Calcium leucovorin 10 mg/m2 p.o. q 6 h X four doses was given 24 h after MTX. The regimen was given on days 1 and 8 and repeated every 28 days. Six of 44 patients (14%) obtained either complete or partial response with a mean response duration of 6.8 months. Of 26 previously untreated patients there were one complete response (4%), four partial responses (15%), and 12 (46%) instances of stabilization of disease. Patients obtaining response or stabilization of disease experienced improved survival compared to those with progressive disease. Toxicity consisted of stomatitis and hematopoietic suppression requiring dose attenuation in six patients (14%); there were no treatment-related deaths. Sequenced MTX/5-FU is modestly active with acceptable toxicity in previously untreated patients with colorectal adenocarcinoma but offers no apparent advantage over single-agent 5-FU.
Author List
Hansen RM, Ritch PS, Anderson TMESH terms used to index this publication - Major topics in bold
AdenocarcinomaAdult
Aged
Antineoplastic Combined Chemotherapy Protocols
Colonic Neoplasms
Female
Fluorouracil
Humans
Leucovorin
Male
Methotrexate
Middle Aged
Rectal Neoplasms
