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Childhood primary cutaneous non-T/non-B lymphoma followed by acute T-cell leukemia. Cancer 1986 Jun 15;57(12):2368-74 PMID: 3486034

Pubmed ID

3486034

Abstract

An 8-year-old girl presented with cutaneous lymphoma without bone marrow or visceral involvement. The tumor cells displayed convoluted and invaginated euchromatic nuclei. The immunophenotype of these cells was non-T/non-B (Ia+, CALLA-, SIg-, TdT-, E-, Thy-). The skin lesions regressed promptly with chemotherapy including cyclophosphamide, vincristine, methotrexate, doxorubicin, and cytosine arabinoside. Six months after the completion of chemotherapy (18 months postdiagnosis), the patient had a relapse of the skin lesions with concurrent bone marrow involvement. The cutaneous infiltrate at relapse was morphologically and immunophenotypically similar to that at the onset of illness. However, the bone marrow infiltrate, although morphologically similar to the cutaneous tumor, had an immunophenotype consistent with T-cells (Ia+, CALLA-, SIg-, E-, TdT+, Thy+, OKT4+, OKT8+). As in adults, primary cutaneous non-T/non-B lymphomas in children may be derived from T-cells or their precursors.

Author List

Tang TT, Lauer SJ, Harb JM, Kirchner PA, Adair SE, Camitta BM

Author

Bruce M. Camitta MD Clinical Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0022572523   2 Citations

MESH terms used to index this publication - Major topics in bold

Acute Disease
Child
Female
Humans
Leukemia
Lymphoma
Microscopy, Electron
Neoplasm Recurrence, Local
Neoplasms, Multiple Primary
Skin Neoplasms
T-Lymphocytes
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e