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The implication of follicular lymphoma patients receiving allogeneic stem cell transplantation from donors carrying t(14;18)-positive cells. Bone Marrow Transplant 2005 Jun;35(11):1049-54 PMID: 15821762

Pubmed ID

15821762

Abstract

We performed real-time quantitative polymerase chain reaction (RQ-PCR) in peripheral blood (PB) and/or bone marrow (BM) samples collected pre- and post transplant from 23 recipient-donor pairs receiving allogeneic stem cell transplantation (allo-SCT) for follicular lymphoma (FL). Of 23 donors, 11 had a PB and/or BM sample positive for t(14;18) (BCL2/IGH fusion) at low levels (<one t(14;18) cell in 10K total cells). Recipients from donors with (n=11) and those without (n=12) detectable t(14:18) cells were similar in age, sex, and disease status pretransplant. No differences in the incidence of graft-versus-host-disease (GVHD), delayed engraftment, relapse rate, disease-free survival and overall survival were identified between the groups. Two recipients without detectable t(14;18) cells pre-transplant showed detectable t(14;18) cells at 2 and 11 years after receiving grafts from donors with t(14:18) cells. Neither patient developed FL 1.5 and 2 years after the emergence of t(14;18) cells. Although the sample size is relatively small, our findings suggest that individuals carrying t(14;18) cells may not be excluded as donors given the lack of an association of t(14;18) detected in donors with adverse clinical outcome. It may be necessary to screen for the donor's t(14;18) status before using t(14;18) for monitoring minimal residual disease by RQ-PCR to exclude the possibility of confounding donor's t(14;18) clone.

Author List

McGregor DK, Keever-Taylor CA, Bredeson C, Schur B, Vesole DH, Logan B, Chang CC

Author

Brent R. Logan PhD Director, Professor in the Institute for Health and Equity department at Medical College of Wisconsin




Scopus

2-s2.0-20044389355   4 Citations

MESH terms used to index this publication - Major topics in bold

Adult
Bone Marrow Cells
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Disease-Free Survival
Female
Graft vs Host Disease
Humans
Lymphoma, Follicular
Male
Middle Aged
Recurrence
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Stem Cell Transplantation
Time Factors
Tissue Donors
Translocation, Genetic
Transplantation, Homologous
Treatment Outcome
jenkins-FCD Prod-297 dff1a717c492f00bf6291286365f1f4fe95208f1