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Mesh term High-Temperature Requirement A Serine Peptidase 2

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Apoptosis Regulatory Proteins
Mitochondrial Proteins
Parkinson Disease Associated Proteins
Serine Endopeptidases

Description

A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.



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jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad