Analysis of lower genital tract lesions clinically suspicious for condylomata using in situ hybridization and the polymerase chain reaction for the detection of human papillomavirus. Arch Pathol Lab Med 1994 Jan;118(1):39-43
Date
01/01/1994Pubmed ID
8285832Scopus ID
2-s2.0-0028029063 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
The presence of human papillomavirus was analyzed in 123 biopsy specimens of lower genital tract lesions, clinically considered to be condyloma, using both in situ hybridization and the polymerase chain reaction. Using standard histologic criteria only 22% of the lesions could be diagnosed as condyloma, 17% had features suggestive but not diagnostic of condyloma and 61% lacked the histologic features of condyloma. Human papillomavirus was detected by in situ hybridization in 89% of the lesions with the histologic features of condyloma but in only 3% of the biopsy specimens lacking the histologic features of condyloma. Fifty percent of lesions that had histologic features suggestive, but not diagnostic for, condyloma contained human papillomavirus by in situ hybridization. Using polymerase chain reaction similar results were found. This study underscores the usefulness of human papillomavirus detection methods for analyzing histologically equivocal lesions of the lower genital tract.
Author List
Felix JC, Wright TCAuthor
Juan Felix MD Vice Chair, Director, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Condylomata AcuminataDNA, Viral
Diagnosis, Differential
Female
Genital Diseases, Female
Genital Diseases, Male
Humans
In Situ Hybridization
Male
Papillomaviridae
Polymerase Chain Reaction