Faculty Collaboration Database

Parathyroid gland hemorrhage in perinatally lethal osteogenesis imperfecta. J Pediatr 1988 May;112(5):720-5

Date

05/01/1988

Pubmed ID

3361382

DOI

10.1016/s0022-3476(88)80688-7

Scopus ID

2-s2.0-0023927759 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

In four neonates with perinatally lethal osteogenesis imperfecta (OI) who survived for more than 9 days after birth, vascular congestion and acute hemorrhage were found in 10 of 11 parathyroid glands; in one neonate, all four parathyroid glands, including the only gland without acute hemorrhage, contained abundant deposits of stainable iron. One neonate had hypocalcemia, and one had both hyperphosphatemia and hypocalcemia. In four neonates with OI who died within 72 minutes of birth, all 10 parathyroid glands demonstrated were free of hemorrhage and hemosiderin deposition. Only minor foci of acute hemorrhage were seen in three of 170 glands in 113 comparison neonates and infants. We conclude that parathyroid gland hemorrhage is common in perinatally lethal OI with survival beyond the immediate period of birth, and is otherwise rare. We speculate that parathyroid hemorrhage may be related to difficulty in maintaining postnatal calcium homeostasis in the absence of adequate calcium reserves in bone. Acute parathyroid gland hemorrhage causes fluctuations in serum calcium levels that have on occasion proved fatal, and parathyroid hemorrhage may be a proximate cause of death in some neonates with OI.

Author List

Knisely AS, Magid MS, Felix JC, Singer DB

Author

Juan Felix MD Vice Chair, Director, Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Female
Hemorrhage
Humans
Infant, Newborn
Male
Osteogenesis Imperfecta
Parathyroid Diseases
Parathyroid Glands