Faculty Collaboration Database

Echocardiographic indices of diastolic function relate to functional capacity and quality of life in ambulatory men with atrial fibrillation. J Am Soc Echocardiogr 2011 May;24(5):533-540.e3

Date

02/25/2011

Pubmed ID

21345648

DOI

10.1016/j.echo.2011.01.008

Scopus ID

2-s2.0-79955479034 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

OBJECTIVE: We sought to explore the reliability of echocardiographic parameters of diastolic function and determine their relationship with functional capacity (New York Heart Association [NYHA] class and 6-minute walk test [6MWT]) and the domains of a health-related quality of life (HR-QOL) questionnaire (Veterans RAND 36-Item Health Survey) in a cohort of ambulatory patients with atrial fibrillation (AF).

METHODS: Forty-eight male veterans with persistent or permanent AF underwent clinical examination, echocardiography, and 6MWT, and filled out a Veterans RAND 36-Item Health Survey questionnaire at two visits 1 week apart. Pairwise correlation was performed to evaluate the reliability of echocardiographic parameters and multiple regression analyses to assess the association of these parameters with functional capacity and HR-QOL.

RESULTS: E/e' average had the highest correlation between the two visits (coefficient: 0.87) and had a significant relationship with NYHA, 6MWT, and physical functioning domain of HR-QOL even after adjusting for confounding variables (odds of NYHA >1: OR 1.5, 95% CI, 1.2-1.9; 6MWT coefficient: -31 ± 9 ft; physical functioning score coefficient: -1.7 ± 0.7).

CONCLUSION: Average E/e' is a reliable diastolic function parameter that also independently relates with functional capacity and HR-QOL in ambulatory patients with atrial fibrillation.

Author List

Punjani S, Wu WC, Cohen S, Sharma SC, Choudhary G

Author

Scott B. Cohen MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acceleration
Aged
Atrial Fibrillation
Confidence Intervals
Diastole
Echocardiography, Doppler
Exercise Test
Health Services
Health Status Indicators
Humans
Male
Odds Ratio
Quality of Life
Reproducibility of Results
Statistics as Topic
Surveys and Questionnaires
Veterans
Walking