Faculty Collaboration Database

The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge, Part II. Tomography 2019 Mar;5(1):99-109

Date

03/12/2019

Pubmed ID

30854447

Pubmed Central ID

PMC6403046

DOI

10.18383/j.tom.2018.00027

Scopus ID

2-s2.0-85069224523 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using the shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure the individual AIF from each data set and submitted the results to the managing center. These AIFs, their reference tissue-adjusted variants, and a literature population-averaged AIF, were used by the managing center to perform SSM PK analysis to estimate K^trans (volume transfer rate constant), v_e (extravascular, extracellular volume fraction), k_ep (efflux rate constant), and τ_i (mean intracellular water lifetime). All other variables, including the definition of the tumor region of interest and precontrast T₁ values, were kept the same to evaluate parameter variations caused by variations in only the AIF. Considerable PK parameter variations were observed with within-subject coefficient of variation (wCV) values of 0.58, 0.27, 0.42, and 0.24 for K^trans, v_e, k_ep, and τ_i, respectively, using the unadjusted AIFs. Use of the reference tissue-adjusted AIFs reduced variations in K^trans and v_e (wCV = 0.50 and 0.10, respectively), but had smaller effects on k_ep and τ_i (wCV = 0.39 and 0.22, respectively). k_ep is less sensitive to AIF variation than K^trans, suggesting it may be a more robust imaging biomarker of prostate microvasculature. With low sensitivity to AIF uncertainty, the SSM-unique τ_i parameter may have advantages over the conventional PK parameters in a longitudinal study.

Author List

Huang W, Chen Y, Fedorov A, Li X, Jajamovich GH, Malyarenko DI, Aryal MP, LaViolette PS, Oborski MJ, O'Sullivan F, Abramson RG, Jafari-Khouzani K, Afzal A, Tudorica A, Moloney B, Gupta SN, Besa C, Kalpathy-Cramer J, Mountz JM, Laymon CM, Muzi M, Kinahan PE, Schmainda K, Cao Y, Chenevert TL, Taouli B, Yankeelov TE, Fennessy F, Li X

Authors

Peter LaViolette PhD Professor in the Radiology department at Medical College of Wisconsin
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Algorithms
Arteries
Contrast Media
Humans
Image Interpretation, Computer-Assisted
Information Dissemination
Magnetic Resonance Imaging
Male
Models, Biological
Neovascularization, Pathologic
Prostatic Neoplasms
Reproducibility of Results