Faculty Collaboration Database

Perioperative blood transfusion increases risk of surgical site infection after bariatric surgery. Surg Obes Relat Dis 2019 Apr;15(4):582-587

Date

02/26/2019

Pubmed ID

30803881

DOI

10.1016/j.soard.2019.01.023

Scopus ID

2-s2.0-85061798542 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

BACKGROUND: Surgical site infection (SSI) is an important marker of postoperative morbidity and overall quality of care. Transfusion-related immunomodulation can lead to weakened immunity in response to blood transfusion and predispose patients to SSIs.

OBJECTIVES: The aim of this study was to determine the impact of perioperative blood transfusions on SSIs in bariatric surgery patients.

SETTING: National data set.

METHODS: The American College of Surgeons National Surgical Quality Improvement Program data sets were queried for laparoscopic and open bariatric operations between 2012 and 2014. Univariate analyses identified perioperative variables associated with postoperative SSIs. Multivariate regression analyses determined the effect of perioperative blood transfusions on postoperative SSI.

RESULTS: The study cohort included 59,424 patients: 480 (8.1%) biliopancreatic diversions, 28,268 (44.2%) gastric bypasses, 30,258 (50.9%) sleeve gastrectomies, and 418 (7.0%) bariatric revisions. Of the patients, 1107 (1.9%) developed a SSI: 662 (1.1%) superficial, 89 (0.1%) deep, and 356 (.6%) organ space. Patients receiving a perioperative blood transfusion were more likely to develop any type of SSI, organ space being most prevalent (Fig. 1). Among organ space SSIs, 198 (55.6%) were gastric bypasses and 125 (35.1%) were sleeve gastrectomies.

CONCLUSIONS: Bariatric surgery patients who receive a perioperative blood transfusion are at higher risk of developing SSIs, particularly organ space. The majority of organ space SSIs occur after gastric bypass, likely secondary to infected intra-abdominal hematomas. Close monitoring of postoperative signs of infection in these patients is important to determine if additional interventions are warranted.

Author List

Higgins RM, Helm MC, Kindel TL, Gould JC

Authors

Jon Gould MD Chief, Professor in the Surgery department at Medical College of Wisconsin
Rana Higgins MD Associate Professor in the Surgery department at Medical College of Wisconsin
Tammy Lyn Kindel MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Bariatric Surgery
Blood Transfusion
Cohort Studies
Female
Humans
Male
Middle Aged
Perioperative Care
Surgical Wound Infection