Development of Secondary Osteosarcoma After TBI and Allogeneic Bone Marrow Transplant: A Case Series of 3 Patients. J Pediatr Hematol Oncol 2020 03;42(2):e100-e103
Date
02/27/2019Pubmed ID
30807391DOI
10.1097/MPH.0000000000001442Scopus ID
2-s2.0-85062182789 1 CitationAbstract
Osteosarcoma can rarely occur as a subsequent malignant neoplasm after cancer therapy. Children who underwent treatment for cancer and received an allogeneic hematopoietic cell transplant are at a higher risk to develop secondary malignancies. Radiation is also a known risk factor, but estimating the quantitative risk is difficult due to the rarity of the condition and long latency period between primary and secondary cancer. In this report, we present 3 patients diagnosed with leukemia as young children who received hematopoietic cell transplants with total body irradiation as part of the conditioning regimen, and later went on to develop secondary osteosarcoma.
Author List
Scheuermann A, Phelan R, Browning MAuthors
Meghen B. Browning MD Associate Professor in the Pediatrics department at Medical College of WisconsinRachel A. Phelan MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentBone Marrow Transplantation
Bone Neoplasms
Child, Preschool
Combined Modality Therapy
Humans
Male
Neoplasms, Second Primary
Osteosarcoma
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Transplantation, Homologous
Whole-Body Irradiation
