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Myeloid malignancies after treatment for solid tumours. Best Pract Res Clin Haematol 2019 Mar;32(1):40-46

Date

04/01/2019

Pubmed ID

30927974

DOI

10.1016/j.beha.2019.02.012

Scopus ID

2-s2.0-85062663467   6 Citations

Abstract

The cure rate for several solid tumour malignancies including breast cancers, head and neck cancers, bone cancers, and sarcoma has improved remarkably with the advent of neoadjuvant and adjuvant therapies. Unfortunately, exposure to chemotherapy or radiation as a part of these treatments exposes patients to the risk of subsequent myeloid malignancies. Therapy related myeloid malignancies have certain characteristic findings. They typically arise within 10 years of treatment exposure, they are seen in younger patients, and the greatest risk is in patients who receive therapy with alkylating agents or topoisomerase II inhibitors. Solid tumours whose therapies utilize these agents at higher doses, namely bone/soft tissue cancers, testicular cancer, anal cancer, and brain tumours, appear to be the groups at highest risk for T-MN. Beyond these patients, emerging populations diagnosed with T-MN include prior platinum exposure, and patients requiring G-CSF support with chemotherapy.

Author List

Guru Murthy GS, Abedin S

Authors

Sameem Abedin MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Guru Subramanian Guru Murthy MD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Chemotherapy, Adjuvant
Female
Granulocyte Colony-Stimulating Factor
Hematologic Neoplasms
Humans
Male
Myeloproliferative Disorders
Neoplasms, Second Primary
Platinum
Risk Factors
Topoisomerase II Inhibitors