Hypertension, insulin resistance, and aldosterone: sex-specific relationships. J Clin Hypertens (Greenwich) 2009 Mar;11(3):130-7
Date
03/24/2009Pubmed ID
19302424Pubmed Central ID
PMC8673362DOI
10.1111/j.1751-7176.2009.00084.xScopus ID
2-s2.0-63349086394 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
African Americans, particularly men, have the highest morbidity and mortality rates from hypertension in the United States. The authors studied 527 African Americans in a general clinical research center to determine whether there are sex differences in the relationships between hypertension with insulin resistance (IR) and aldosterone, which are risk factors for cardiovascular disease. Measurements included ambulatory blood pressure (BP), anthropometric measures, plasma renin activity, plasma aldosterone (PA) concentration, and fasting serum lipids, glucose, and insulin. IR was estimated using the Homeostasis Model Assessment (HOMA) model. BP correlated with aldosterone in both sexes. However, both BP and PA correlated with IR in men, but not in women. Compared with men in the lower tertile of HOMA-IR, men in the upper tertile had higher mean systolic BP, a higher odds ratio of having hypertension, and higher levels of PA. The association of IR with both hypertension and PA in men, but not in women, may contribute to the high prevalence of cardiovascular disease in African American men.
Author List
Kidambi S, Kotchen JM, Krishnaswami S, Grim CE, Kotchen TAAuthor
Srividya Kidambi MD Sr Medical Director, Chief, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Age Factors
Aldosterone
Anthropometry
Blood Glucose
Blood Pressure Determination
Cardiovascular Diseases
Cohort Studies
Female
Genetic Predisposition to Disease
Humans
Hypertension
Insulin Resistance
Male
Metabolic Syndrome
Middle Aged
Prevalence
Prognosis
Renin
Risk Factors
Sex Factors
Survival Analysis
United States
Young Adult
