Medical College of Wisconsin
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Influence of early life events on health and diseases. Trans Am Clin Climatol Assoc 2006;117:313-9; discussion 319-20

Date

06/06/2008

Pubmed ID

18528483

Pubmed Central ID

PMC1500933

Scopus ID

2-s2.0-63449140550   8 Citations

Abstract

The transition from the fetal to the extrauterine environment is associated with complex physiological adjustments and involves numerous cardiovascular, pulmonary, and metabolic adjustments to ensure successful adaptation to the postnatal life. While such changes are in response to the altered environment in which the newborn finds itself, external changes affecting the fetal environment could impact the integrity of these mechanisms and increase susceptibility to diseases later in life. The present article reviews some of the mechanisms involved in the transition from fetal to postnatal life and focuses of how our health as adults is dependent on the conditions we experienced in-utero.

Author List

Robillard JE, Segar JL

Author

Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Animals
Birth Weight
Disease
Female
Fetus
Glucocorticoids
Health Status
Humans
Infant, Newborn
Male
Pregnancy
Prenatal Exposure Delayed Effects
Renin-Angiotensin System
Risk Factors
Sympathetic Nervous System
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00