Influence of early life events on health and diseases. Trans Am Clin Climatol Assoc 2006;117:313-9; discussion 319-20
Date
06/06/2008Pubmed ID
18528483Pubmed Central ID
PMC1500933Scopus ID
2-s2.0-63449140550 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
The transition from the fetal to the extrauterine environment is associated with complex physiological adjustments and involves numerous cardiovascular, pulmonary, and metabolic adjustments to ensure successful adaptation to the postnatal life. While such changes are in response to the altered environment in which the newborn finds itself, external changes affecting the fetal environment could impact the integrity of these mechanisms and increase susceptibility to diseases later in life. The present article reviews some of the mechanisms involved in the transition from fetal to postnatal life and focuses of how our health as adults is dependent on the conditions we experienced in-utero.
Author List
Robillard JE, Segar JLAuthor
Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnimals
Birth Weight
Disease
Female
Fetus
Glucocorticoids
Health Status
Humans
Infant, Newborn
Male
Pregnancy
Prenatal Exposure Delayed Effects
Renin-Angiotensin System
Risk Factors
Sympathetic Nervous System
