Faculty Collaboration Database

Depression and all-cause and coronary heart disease mortality among adults with and without diabetes. Diabetes Care 2005 Jun;28(6):1339-45

Date

05/28/2005

Pubmed ID

15920049

DOI

10.2337/diacare.28.6.1339

Scopus ID

2-s2.0-19944411495 (requires institutional sign-in at Scopus site)   369 Citations

Abstract

OBJECTIVE: The aim of this study was to evaluate the effect of depression on all-cause and coronary heart disease (CHD) mortality among adults with and without diabetes.

RESEARCH DESIGN AND METHODS: We studied 10,025 participants in the population-based National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study who were alive and interviewed in 1982 and had complete data for the Center for Epidemiologic Studies Depression Scale. Four groups were created based on diabetes and depression status in 1982: 1) no diabetes, no depression (reference group); 2) no diabetes, depression present; 3) diabetes present, no depression; and i4) diabetes present, depression present. Cox proportional hazards regression models were used to calculate multivariate-adjusted hazard ratios (HRs) of death for each group compared with the reference group.

RESULTS: Over 8 years (83,624 person-years of follow-up), 1,925 deaths were documented, including 522 deaths from CHD. Mortality rate per 1,000 person-years of follow-up was highest in the group with both diabetes and depression. Compared with the reference group, HRs for all-cause mortality were no diabetes, depression present, 1.20 (95% CI 1.03-1.40); diabetes present, no depression 1.88 (1.55-2.27); and diabetes present, depression present, 2.50 (2.04-3.08). HRs for CHD mortality were no diabetes, depression present, 1.29 (0.96-1.74); diabetes present, no depression 2.26 (1.60-3.21); and diabetes present, depression present, 2.43 (1.66-3.56).

CONCLUSIONS: The coexistence of diabetes and depression is associated with a significantly increased risk of death from all causes, beyond that due to having either diabetes or depression alone.

Author List

Egede LE, Nietert PJ, Zheng D

Author

Leonard E. Egede MD Center Director, Chief, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cohort Studies
Coronary Disease
Demography
Depression
Diabetic Angiopathies
Female
Follow-Up Studies
Health Surveys
Humans
Life Style
Male
Middle Aged
Probability
Proportional Hazards Models
Surveys and Questionnaires
Survival Analysis
Time Factors