Neurocognition in individuals with incidentally-identified meningioma. J Neurooncol 2017 Aug;134(1):125-132
Date
05/27/2017Pubmed ID
28547588Pubmed Central ID
PMC5544551DOI
10.1007/s11060-017-2495-8Scopus ID
2-s2.0-85019702070 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
Meningiomas are primary intracranial tumors that are often asymptomatic. To our knowledge, no study has attempted to describe neurocognitive function in patients with incidentally-discovered meningioma. We utilized the Mayo Clinic Study of Aging (MCSA), which is a population-based sample of Olmsted County, Minnesota residents that includes neuropsychological testing and brain MRI approximately every 15 months. Using a text search of radiologists' notes of 2402 MCSA individuals (mean age 77 years, scanned between 2004 and 2014) we identified 48 eligible subjects (2%) who had at least one meningioma. Most meningiomas were small (90% <3 cm). We matched each of the 48 subjects to 5 non-demented MCSA controls (n = 240) on age, sex, and education. Cognitive domains assessed included memory, attention-executive function, language, and visuospatial. More women (67%) had a meningioma than men (33%). Groups did not differ on prevalence of Mild Cognitive Impairment (Meningioma = 19%, Controls = 13%). Across cognitive domains, we observed similar performance for the two groups (p's ≥ 0.21). Subtle differences emerged in memory and language domains (p = 0.05 and p = 0.11) when we divided the Meningioma group by tumor location, wherein the small group with an infratentorial tumor performed more poorly than controls globally as well as on select memory and language measures. Our findings suggest that small meningiomas are generally cognitively benign, but that may change as the tumor evolves, and might be impacted by other factors such as meningioma location.
Author List
Butts AM, Weigand S, Brown PD, Petersen RC, Jack CR Jr, Machulda MM, Cerhan JHAuthor
Alissa Butts PhD Associate Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Analysis of Variance
Apolipoproteins E
Attention
Cognition Disorders
Community Health Planning
Female
Humans
Language
Longitudinal Studies
Magnetic Resonance Imaging
Male
Memory
Meningeal Neoplasms
Meningioma
Middle Aged
Neuropsychological Tests
Visual Perception
