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Brain death interval and relationship to outcomes of pediatric cardiac transplantation. Pediatr Transplant 2019 Jun;23(4):e13426

Date

05/08/2019

Pubmed ID

31062919

DOI

10.1111/petr.13426

Scopus ID

2-s2.0-85065481480 (requires institutional sign-in at Scopus site)

Abstract

BACKGROUND: We sought to analyze brain death interval and outcomes of pediatric cardiac transplantation using national registry data.

METHODS: We retrospectively evaluated a pediatric cohort from the UNOS registry from 2005 to 2014. We restricted the donor cohort to those with a primary central nervous system event as the cause of hospitalization. Brain death interval (BDI) was defined as the time between hospital admission and organ procurement. Primary outcomes were recipient and graft survival time. Logistical regression modeling was used for multivariable analysis.

RESULTS: The donor cohort included 2565 cases. Multivariable analysis demonstrated no relationship between BDI and recipient or graft survival time. For patient survival time, the lowest HR was 0.94 (0.63-1.39), P = 0.531; for graft survival time, the lowest HR was 0.89 (0.53-1.49), P = 0.563. We obtained similar results using a non-restricted donor cohort.

CONCLUSIONS: There was no clear relationship between BDI and recipient or graft survival after pediatric cardiac transplantation.

Author List

Grosshuesch C, Johnson WK, DeVogel N, Yin Z, Wang T, Kindel SJ, Woods RK

Authors

Steven J. Kindel MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tao Wang PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
Ronald K. Woods MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Aorta
Brain Death
Child
Child, Preschool
Female
Graft Rejection
Graft Survival
Heart Failure
Heart Transplantation
Humans
Infant
Kaplan-Meier Estimate
Male
Multivariate Analysis
Registries
Regression Analysis
Retrospective Studies
Tissue Donors
Tissue and Organ Procurement
Treatment Outcome