Prevalence and factors associated with malnutrition in older patients with cancer. J Geriatr Oncol 2019 Sep;10(5):763-769
Date
04/16/2019Pubmed ID
30982752DOI
10.1016/j.jgo.2019.01.021Scopus ID
2-s2.0-85064172233 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
BACKGROUND: >60% of patients with cancer are 65 years of age and older, and malnutrition is commonly encountered in older adults.
OBJECTIVE: To assess the prevalence and factors associated with malnutrition in older patients with cancer.
METHODS: In this cross-sectional study, patients with cancer underwent a comprehensive geriatric assessment (CGA). Malnutrition status was diagnosed by clinical assessment including screening tools such as Mini Nutrition Assessment (MNA), weight loss, and BMI.
ANALYSIS: Descriptive statistics, chi-Square and logistic regression analysis were used to assess factors associated with malnutrition.
RESULTS: A total of 454 patients with malnutrition information available were included in analysis. The median age was 78, range 65-96 years and comorbid diagnoses included dementia, mild cognitive impairment, frailty, and functional impairment. A total of 41.9% (n = 190) were diagnosed with malnutrition during the CGA. In the multivariable analysis, major depression and frailty were significantly associated with malnutrition. After controlling for potential confounders, patients who had malnutrition were 2.53-times more likely to have major depression (OR = 2.53, 95% CI: 1.23-5.24, p = 0.01) and 3.82 times more likely to have frailty (OR = 3.82, 95% CI: 1.35-10.84, p = 0.01) than those without malnutrition.
CONCLUSIONS: Despite significant advances in cancer and supportive care, malnutrition remains a significant and highly prevalent public health problem among older patients with cancer. Identifying factors associated with risk for malnutrition in this patient population can help develop preventive strategies as part of care. Prospective studies are recommended.
Author List
Zhang X, Pang L, Sharma SV, Li R, Nyitray AG, Edwards BJAuthor
Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Activities of Daily LivingAged
Aged, 80 and over
Cognitive Dysfunction
Comorbidity
Dementia
Depressive Disorder, Major
Female
Frailty
Geriatric Assessment
Humans
Male
Malnutrition
Neoplasms
Nutrition Assessment
Prevalence
Risk Factors
Vitamin D Deficiency
Walking Speed
