Opening the black box: Stem cell-based modeling of human post-implantation development. J Cell Biol 2019 Feb 04;218(2):410-421
Date
12/16/2018Pubmed ID
30552099Pubmed Central ID
PMC6363460DOI
10.1083/jcb.201810084Scopus ID
2-s2.0-85061053586 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Proper development of the human embryo following its implantation into the uterine wall is critical for the successful continuation of pregnancy. However, the complex cellular and molecular changes that occur during this post-implantation period of human development are not amenable to study in vivo. Recently, several new embryo-like human pluripotent stem cell (hPSC)-based platforms have emerged, which are beginning to illuminate the current black box state of early human post-implantation biology. In this review, we will discuss how these experimental models are carving a way for understanding novel molecular and cellular mechanisms during early human development.
Author List
Taniguchi K, Heemskerk I, Gumucio DLAuthor
Kenichiro Taniguchi PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsEmbryo, Mammalian
Embryonic Development
Humans
Models, Biological
Pluripotent Stem Cells