Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Opening the black box: Stem cell-based modeling of human post-implantation development. J Cell Biol 2019 Feb 04;218(2):410-421

Date

12/16/2018

Pubmed ID

30552099

Pubmed Central ID

PMC6363460

DOI

10.1083/jcb.201810084

Scopus ID

2-s2.0-85061053586 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

Proper development of the human embryo following its implantation into the uterine wall is critical for the successful continuation of pregnancy. However, the complex cellular and molecular changes that occur during this post-implantation period of human development are not amenable to study in vivo. Recently, several new embryo-like human pluripotent stem cell (hPSC)-based platforms have emerged, which are beginning to illuminate the current black box state of early human post-implantation biology. In this review, we will discuss how these experimental models are carving a way for understanding novel molecular and cellular mechanisms during early human development.

Author List

Taniguchi K, Heemskerk I, Gumucio DL

Author

Kenichiro Taniguchi PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Embryo, Mammalian
Embryonic Development
Humans
Models, Biological
Pluripotent Stem Cells