An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease. J Matern Fetal Neonatal Med 2009 Mar;22(3):233-8
Date
03/31/2009Pubmed ID
19330707Pubmed Central ID
PMC2833315DOI
10.1080/14767050802488220Scopus ID
2-s2.0-67650491491 (requires institutional sign-in at Scopus site) 41 CitationsAbstract
OBJECTIVES: Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. We describe other manifestations of cardiac disease.
METHODS: We describe three fetuses with unique myocardial and conduction system disease.
RESULTS: One had isolated EFE with subsequent mitral and tricuspid valve chordal avulsion, the second had sinoatrial and infrahissian conduction system disease, and in both, neonatal progression to life threatening disease occurred. The third had sinus node dysfunction and atrial flutter.
CONCLUSION: These findings expand the clinical phenotype of maternal SSA/SSB antibody associated fetal cardiac disease.
Author List
Cuneo BF, Strasburger JF, Niksch A, Ovadia M, Wakai RTAuthor
Janette F. Strasburger MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAutoantibodies
Autoantigens
Cardiomyopathies
Female
Fetal Diseases
Heart Block
Humans
Infant, Newborn
Infant, Newborn, Diseases
Magnetocardiography
Male
Phenotype
Pregnancy
Ribonucleoproteins
Sjogren's Syndrome
