Faculty Collaboration Database

Neither L-arginine nor L-NAME affects neurological outcome after global ischemia in cats. Stroke 1997 Nov;28(11):2259-64; discussion 2264-5

Date

11/22/1997

Pubmed ID

9368574

DOI

10.1161/01.str.28.11.2259

Scopus ID

2-s2.0-0030694289 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

BACKGROUND AND PURPOSE: We attempted to determine whether N-nitro-L-arginine methyl ester (L-NAME) would improve neurological outcome and whether L-arginine (L-ARG) would worsen neurological outcome after transient global ischemia.

METHODS: Halothane-anesthetized cats (n = 6 for each group) were treated with intravenous saline, L-NAME (5 mg/kg or 10 mg/kg), or L-arginine (300 mg/kg) 30 minutes before 10 minutes of ischemia (temporary ligation of the left subclavian and brachiocephalic arteries with hemorrhagic hypotension to 50 mm Hg). At 30 minutes of reperfusion, cats in the L-ARG group were administered an additional 300 mg/kg dose of intravenous L-arginine.

RESULTS: Time (mean +/- SE) to isoelectric electroencephalography was similar among groups (saline, 26 +/- 11 seconds; L-NAME-5, 15 +/- 4 seconds; L-NAME-10, 36 +/- 27 seconds; and L-ARG, 22 +/- 7 seconds). At 72 hours, reperfusion pathological injury was severe and neurological deficit score (mean, range) was similar among groups (saline, 38[11 to 70]; L-NAME-5, 52 [40 to 73]; L-NAME-10, 47 [23 to 70]; and L-ARG, 40 [0 to 79]).

CONCLUSIONS: Nitric oxide is not important in the mechanism of brain injury after global ischemia in cats.

Author List

Kirsch JR, Bhardwaj A, Martin LJ, Hanley DF, Traystman RJ

MESH terms used to index this publication - Major topics in bold

Animals
Arginine
Blood Pressure
Brain Ischemia
Cats
Cell Death
Electroencephalography
Enzyme Inhibitors
Hippocampus
Male
NG-Nitroarginine Methyl Ester
Nervous System
Reperfusion Injury