Faculty Collaboration Database

Cerebrovascular CO2 reactivity during delayed vasospasm in a canine model of subarachnoid hemorrhage. Stroke 1991 Mar;22(3):367-72

Date

03/01/1991

Pubmed ID

1900646

DOI

10.1161/01.str.22.3.367

Scopus ID

2-s2.0-0025924557 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

While the in vitro reactivity of cerebral conducting vessels following subarachnoid hemorrhage has been extensively studied, in vivo cerebrovascular CO2 reactivity has not been systematically investigated. We tested the hypothesis that, in the canine model of subarachnoid hemorrhage, the rise in cerebral blood flow normally seen with hypercapnia is blunted during delayed vasospasm. Four groups of animals were studied: one received two 4-ml subarachnoid injections of nonheparinized arterial blood into the cisterna magna (n = 8), one received three subarachnoid injections of 5 ml blood (n = 5), one received two subarachnoid injections of 4 ml saline (n = 5), and a control group (n = 5) had no subarachnoid injections or angiography. Basilar artery diameter was measured from baseline and follow-up angiography. We determined CO2 reactivity by randomly varying the concentration of inspired CO2 and measuring regional cerebral blood flow with radiolabeled microspheres. Basilar artery diameter was not affected by saline injection and was reduced by 26 +/- 2.9% in the two-hemorrhage group and 55 +/- 1.9% in the three-hemorrhage group. Baseline cerebral blood flow and CO2 reactivity were similar in all four groups. We conclude that, in this model of delayed vasospasm, regional cerebral vascular CO2 reactivity is intact and extrapolation of in vitro data regarding basilar artery diameter and reactivity to cerebral blood flow must be done cautiously.

Author List

Diringer MN, Heffez DS, Monsein L, Kirsch JR, Hanley DF, Traystman RJ

Author

Dan S. Heffez MD Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Basilar Artery
Blood Pressure
Carbon Dioxide
Cerebrovascular Circulation
Disease Models, Animal
Dogs
Hydrogen-Ion Concentration
Ischemic Attack, Transient
Male
Oxygen
Partial Pressure
Radiography
Reference Values
Subarachnoid Hemorrhage